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Decreased activity of GPX4 prevents the metabolism of lipid peroxides via GPX4-catalyzed glutathione (GSH) reduction reactions, resulting in the oxidation of divalent iron ions and the generation of reactive oxygen species (ROS) in lipids (19)

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Decreasing glutathione by reducing expression of the -GLUTAMYLCYSTEINE SYNTHETASE ( GSH1 ), the rate-limiting enzyme for glutathione biosynthesis, restored the size defect of smt15-1 mutant by increasing its daughter cell size, confirming that glutathione modulates the cell-size control mechanism of smt15-1 mutant

In genetically engineered mouse models (GEMMs), constitutive deletion of Egfr , specifically in myeloid cells before tumor initiation, led to reduced tumor burden in CRC and HCC, whereas EGFR deletion in tumor cells (intestinal epithelial cells and hepatocytes) did not affect (CRC) or even enhanced (HCC) tumor growth [8, 9]

Furthermore, tranilast has been investigated in Phase II clinical trials in combination with allopurinol for patients experiencing moderate-to-severe gouty arthritis