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Description
In the United Kingdom, vitamin B12 deficiency is relatively common, with prevalence varying depending on the population studied and the biochemical threshold used for diagnosis

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The latter is characterized by increased production of pro-inflammatory cytokines and enhanced ROS generation, increasing intestinal barrier dysfunction

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While this is not exact information about first usage of a given substance as a pesticide, it provides a good approximation of when a given compound has entered the public domain
