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At minimum, check metabolic panels, liver function, lipid profiles, and fasting glucose before starting and every 8-12 weeks during combination therapy

Stomach acid and enzymes free vitamin B 12 from food, allowing it to bind to R-protein (formerly known as transcobalamin I and now called haptocorrin), found in saliva and gastric fluids

Raw material lots from B12 suppliers can differ slightly

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Synergistic compounds working through different mechanisms can make each component more effective