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Indeed, they could be employed as CRC biomarkers

If you live with diabetes, peripheral neuropathy can cause you to become unable to feel temperature changes and pain in your feet, legs, arms, or hands, putting you at risk for wounds and infections that can quickly become life-threatening

Pain assessment is particularly important for selecting effective pharmacological and non-pharmacological interventions during dressing changes and other procedures, as well as during routine daily activities

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CNS neuroscience & therapeutics, 26(1), 5-13.