glutathione role in liver detoxification Glutathione-mediated biotransformation the modulates nanoparticle transport A Literature Review of Glutathione

8: 102 Dotson D

Lancet 379 , 12561268 (2012)

The members of the first class of Grxs, often referred to as class I or dithiol Grxs, share a common CPYC motif in their active sites

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Disulfide bonds within these cleavable linkers remain stable in the relatively oxidizing conditions of the bloodstream but are cleaved in the reducing environment of the cytoplasm, thereby releasing the cytotoxic drug specifically within cancer cells