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10.1136/jmedgenet-2012-100836 J
The mechanism of Pb 2+ toxicity involves altered mitochondrial permeability, the release of mitochondrial proteins resulting in the apoptosis of brain cells, an increase in the proapoptotic Bax/Bcl-2 ratio via the downregulation of the antiapoptotic protein Bcl-2, and the upregulation of the proapoptotic protein Bax (Pulido and Parrish 2003
Zinc deficiency results in a reduction of function and/or dysfunction of all immune cells [45]
Bi, S., Huang, Z., Wang, Y., Nie, F., Wang, X., Sun, L., Zhu, Z., Gooneratne, R., 2019
In the context of the tendons inflammatory response, STAT3 displays dual regulatory roles, although the exact mechanisms remain unclear
