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While the passive technique focuses on drug and vehicle interaction and optimization to affect the stratum corneum structure, the active approach utilizes external energy to facilitate the transportation of drugs through the skin or by physically disrupting the outermost layer of the skin, known as the stratum corneum [230, 231]

doi: 10.1080/21642850.2014.905207 76 ScottAJWebbTLMartyn-St-JamesMRowseGWeichS

Research Methodology The search for the above-mentioned bioactive effects and clinical impact of ALA was performed in PubMed database, articles published in English were selected, from 2014 to 2019