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In summary, these results demonstrated that the isotopologue similarity networking approach can resolve both previously characterized and uncharacterized metabolic reactions associated with glutathione metabolism, charting a complete glutathione-centered metabolic reaction network (Fig

In clinical practice at ARTC, athletes with chronic tendinopathies that resisted conventional treatment for years often experience complete resolution within 68 weeks

For example, antibiotics that induce ROS, like -lactams or aminoglycosides, often cause bacteria to up-regulate the pentose phosphate pathway for NADPH production, which feeds GSH

Then, a six-point tenfold dilution series was prepared for each compound