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Lung tissue is highly vulnerable to injury following limb IRI
Research highlights its regenerative and anti-inflammatory properties, making it ideal both as an injectable and post-procedure adjunct (NIH)

In contrast, unconstrained swelling significantly increased matrix distortion, glycosaminoglycan loss, exposure of integrin binding sites, expression of MMPs 1 and 3, and collagen denaturation

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Moreover, the increased expression of Cdc42, in conjunction with aPKC, affected the distribution of protein polarization in epithelial cells
