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Symptomatic treatment should also be considered in WD patients with persistent or deteriorating neurological symptoms during WD treatment 170
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In principle, the photosensitizer administrated to the tumor site can react directly with nucleic acid, protein, or unsaturated lipid to generate ROS such as O 2 , OH, or hydrogen peroxide (H 2 O 2 ) in the presence of oxygen (O 2 ) through proton or electron transfer (namely the type I reaction)
and Danovska M., The Nonmotor Symptomschallenge in Diagnosis of Parkinson's Disease, Journal of IMAB 26, no
