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In HT, Th lymphocytes produce cytokines that induce thyroid follicular cells to express surface Human Leukocyte Antigen DR (HLA-DR), thereby making them susceptible to immune attack

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Matsuo Y, Nakamura S, Adachi T, Tsubota T

Mice treated with MOTS-c showed dramatic resistance to diet-induced obesity even without changes in caloric intake

While IGF-1 has important physiological functions, elevated levels carry potential concerns including increased cell proliferation that may support tumor growth in individuals with cancer or pre-cancerous conditions, accelerated aging processes through growth pathway activation, potential cardiovascular effects with chronic elevation, and metabolic consequences including effects on glucose and lipid metabolism