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G., Plecko, B., Roschinger, W., Schwab, K

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Interestingly, the aryl hydrocarbon receptor (AhR) of the tryptophan-kynurenine pathway serves as a critically important mediator between tryptophan metabolism, immune reactions, and tissue homeostasis (4143), and several kynurenine metabolites have been associated with fatigue (44, 45)

Stronger effects observed in older adult populations may reflect unique pathophysiological mechanisms of late-life depression, including mitochondrial dysfunction and neurodegenerative processes, which ALC could plausibly target