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This is due to the models ability to resemble more closely the organotypic histomorphology and microenvironment of hepatocytes in the liver in vivo (Lv et al., 2017), the impact of metabolic cooperation between different cell types on metabolic profiling and long-term survival being metabolically competent

In contrast, dietary hormesis represents a more holistic concept

The effectiveness of these hybrids may be influenced by the electronic nature of the substituents, as evidenced by the fact that the 3,4-dichlorobenzoylpiperidine analog of 1a is more potent than its 3,4-dimethyl equivalent