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However, the intermittent, not continuous, administration of senolytics reduces concerns of toxicity, and effectively circumvents potential off-target effects due to continuous receptor occupancy or modulation of an enzyme or biochemical pathway

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Limited ability to block infections What has become clear is that first-generation vaccines are somewhat limited in their ability to prevent infections, with an efficacy of ~75% for preventing symptomatic infections but only ~45% for preventing asymptomatic infections [5]

Back Talmage, DW (1957) 'Allergy and immunology', Annual Reviews of Medicine , 8, 239-56

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