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Pregnancy and breastfeeding: No safety data exists for use during pregnancy or lactation

Nonteratogenic Effects: Because of the known effects of nonsteroidal anti-inflammatory drugs on the fetal cardiovascular system (closure of ductus arteriosus), use during pregnancy (particularly late pregnancy) should be avoided

having a fixed dosing schedule does not make sense for people who already have the necessary immunity

Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets