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Curcumin induced inhibition of AP-1 was a result of its direct interface with AP-1 DNA binding motif ( 3 and NF-B was inhibited by curcumin, leading to the down-regulations of genes involved in apoptosis and cellular proliferation (Mackenzie et al., 2008)

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Unlike its derivates, such as nicotinic acid, nicotinamide riboside, and nicotinamide mononucleotide, which may cause side effects like flushing, itching, hypotension, and headaches, NAM is generally safe and well-tolerated, even at high doses (up 3 mg/die), with rare adverse effects observed over prolonged treatments [10,11,12]

Chong, J., Uren, A., Rubin, J