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Taken together, these findings demonstrate that Hb, particularly astrocytic Hb in the hippocampus and both astrocytic and neuronal Hb in the SNpc, is essential for the therapeutic effects of KDS12025, underscoring its pivotal role in mitigating oxidative stress and neurodegeneration in AD and PD models
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CONCLUSIONS The administration of cannabis for 24 days in mice resulted in decreased brain oxidative stress but induced a significant increase in immobility in the forced-swimming test and a decrease in the rearing activity, suggesting a depressant- and anxiety-like effect
A 12-week, 90 subject clinical study of the effects of SF on depression is ongoing in Changsha, China, at the time of this writing (NCT04246905)
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