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The two most notorious culprits are Proton Pump Inhibitors (PPIs) , used for acid reflux, and Metformin , the first-line treatment for Type 2 diabetes

The big difference is supposed to be that chemical agents absorb UV-light while physical agents reflect it like a bunch of mini umbrellas on top of the skin

Wasyeczko M, Sikorska W, Chwojnowski A (2020) Review of synthetic and hybrid scaffolds in cartilage tissue engineering

T-type calcium channels also play a significant role in the pathophysiology of myocardial iron overload, particularly in patients with -thalassemia