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M., Sies H

N Engl J Med 2012;367(9):795804

Just a reasonable dose and the discipline to check in on levels periodically

This effect was associated with increased expression of IGF-1 and VEGF in the primary ossification zone.103 Altogether, the bone anabolic actions of the GH can be, at least in part, mediated by paracrine IGF-1 signaling, which enhances osteoblast activity.104 In fact, the only administration of recombinant IGF-1 to healthy participants results in an increase in circulating levels of bone remodeling markers

Another key player is the p53 gene, which is now recognized as a cancer suppressor and important regulator of microenvironment in the stem cell niche [ 13 ]