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The statistics are pretty good

as a result, most controlled efficacy studies referenced to date use parenteral dosing with defined schedules to sustain ERR activation

[DOI] [PubMed] [Google Scholar] 91.Wadiche J.I., Amara S.G., Kavanaugh M.P
Kong, Nrf2 plays an important role in coordinated regulation of Phase II drug metabolism enzymes and Phase III drug transporters
doi: 10.1016/S0952-7915(98)80114-3
