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Restoration of DLEC1 expression resulted in reduced anchorage-independent growth of HT29 cells, indicating suppressed tumorigenic potential (17)

Several NADPH oxidases may play a role in blood pressure control (21), and ROS from NADPH oxidases can also trigger adaptive signaling that improves glutathione replenishment via redox-dependent increases in glutathione reductase activity

In addition, the dual InsR/IGF-IR inhibitor linsitinib can prevent the emergence of breast cancer cells that are resistant to long-term estrogen deprivation or antiestrogen treatment and inhibit growth of established ER+ breast cancer xenografts in ovariectomized mice [107]

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