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Metabolic vulnerabilities and targeted therapies This reliance on mitochondrial respiration exposes a specific therapeutic vulnerability

Sinecatechins, a fraction derived from green tea extract, have been approved by the U.S

N -acetylcysteine (NAC), a synthetic derivative of the endogenous amino acid L-cysteine and a precursor of GSH, has been used for several decades as a mucolytic and as an antidote to acetaminophen (paracetamol) poisoning

This accumulation results in mitochondrial dysfunction, impaired synaptic structure and function, and an imbalance of protein homeostasis

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