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Molecular mechanisms of action of systemic lidocaine in acute and chronic pain: A narrative review

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Inhibitory kinetic studies Inhibitory kinetic studies were performed in the absence and presence of increasing concentrations (0.25, 0.5, 1, and 2 mM) of IAA, IPA, and IBA

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Basic pharmacokinetic parameters including absorption, distribution, metabolism, and excretion characteristics in human subjects would inform rational dosing strategies and identify potential sources of pharmacokinetic variability affecting individual response