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Therefore, one of the therapeutic strategies in cancer should be considered the depletion of the cellular antioxidative systems, among which GSH is one of the main actors [19]

However, brain-targeted delivery systems targeting the insulin receptor remain understudied, likely due to the high cost of using insulin or insulin analogs as ligands and the risk of degradation or inactivation before reaching target tissues

Meth Enzymol 186, 310318

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[DOI] [PubMed] [Google Scholar] 28.Zohrer E., Alisi A., Jahnel J., Mosca A., Della Corte C., Crudele A., Fauler G., Nobili V