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This is different from freezing AFTER reconstitution (which is harmful)

Vitamin deficiencies arise when dietary intake, absorption, or metabolic conversion of specific micronutrients is insufficient

While I cant say exactly how much you should be using I can give you some pertinent information that will help guide you

Metabolic Regulators Metabolic health is inextricably linked to longevity

Vitamin B12 is the most chemically complex of all the vitamins, and cyanocobalamin and hydroxycobalamin are synthetically derived therapeutic forms of vitamin B12.6 Hydroxycobalamin protein binding capacity is greater than that of cyanocobalamin and both of them may cause allergic reactions.6 Vitamin B12 may lead to allergic reactions because of its cobalt molecule, molecular complexity or high molecular mass