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[Accessed: 14 December 2021]

Despite consumption of methionine being essential for survival, studies have shown that limiting methionine in the diet of animals or in cell culture media provides metabolic benefits such as decreasing adiposity [13,14,15,16,17,18,19,20,21], increasing insulin sensitivity [15,16,17,20,21,22], decreasing inflammation [23,24,25], and oxidative stress [26,27,28,29,30,31,32,33], and extending lifespan [34,35,36]

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In addition, based on clinical research, it is important to identify the syndromes and conditions that can benefit from the KD-based therapies, contraindications for use, KD variants with good effectiveness and tolerability, and factors and biomarkers that can predict KD-related outcomes, which may collectively guide the clinical utilization of the KD in different diseases