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However, CRISPR-mediated knockout of AIFM1 fails to protect cells from GPX4 depletion-induced ferroptosis [107]

Conversely, the human body has natural antioxidant systems, which include an enzymatic antioxidant system comprising superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), among others (Napolitano et al., 2021)

Cancer Med 4, 278292.CrossRefGoogle Scholar Bawadood, AS, Al-Abbasi, FA, Anwar, F, El-Halawany, AM & Al-Abd, AM (2020) 6-Shogaol suppresses the growth of breast cancer cells by inducing apoptosis and suppressing autophagy via targeting notch signaling pathway

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It is believed that the accumulation of such high vitamin C concentrations indicates important functions within these cells