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Niacinamide 5-10%: Inhibits the transfer of melanin from melanocytes to keratinocytes, which is the mechanism by which pigment moves into the visible skin layers

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10.1371/journal.pone.0058004 54 JiangG.WangB.WangY.KongH.WangY.GaoP.et al (2023)

Induction of Nrf2 Encoded by the Nfe2l2 gene, Nrf2 is a master regulator of multiple antioxidant enzymes such as HO-1, NQO1, CAT, SOD, glutathione peroxidase (GPx), GST, therodoxins, and glutamatecysteine ligase (GCL)

24,25 The role of neutrophils is also relevant