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BTZ induces the expression of activating transcription factor 3 and c-Jun in DRG neurons, which form a transcriptional heterodimer that upregulates CCL2 and promotes mechanical allodynia, with dose- and time-dependent variation observed in some models (Yamamoto et al., 2015

This effect renders traditional 5-ALA-PDT unable to eliminate malignant tumors because of an inadequate PpIX concentration and a short treatment time window

Glutathione is the most powerful antioxidant in the body, which can help reduce inflammation and improve detoxification in the body

doi: 10.3390/microorganisms10020234 33 ToralMGmez-GuzmnMJimnezRRomeroMSnchezMUtrillaMPet al

Microbiol Spectr 5(5):BAD-0018-2016
