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250 to 500 mcg once daily in the morning on an empty stomach

42 Another RCT studied cyano-B12, 1500 g three times per day for 2 weeks (route not reported), in patients with seasonal affective disorder and found no improvements in either the B12 or the placebo group

More significantly, MOTS-c administration shifted the trajectory of age-related metabolic decline, indicating that the peptide's benefits are not limited to preventing dysfunction in young animals but can partially reverse established decline [2]