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ACS Biomater Sci Eng 11:25282549

[47] Adeoye O, Olawumi J, Opeyemi A, Christiania O

In the liver, SAMe inhibits MTHFR and MS and activates CBS (Lu and Mato, 2008)

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Protein covalent modification by AGEs results in functional impairment and formation of toxic protein inclusions associated with various NGDs It has been understood that post-translational modification of proteins brings about alteration in the native state structural integrity leading to at least 2 consequences (Figure 1)
