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It is a critical regulator of antioxidant activity, detoxification, and immune function

[DOI] [PubMed] [Google Scholar] 191.Yehuda S., Carasso R.L

Sola 13 , 163167 (2017)

Activation of JNK then initiates a cascading effect, with translocation of phosphorylated JNK to the mitochondrial outer membrane58, where it binds with the Sab protein and initiates an Src-mediated inhibition of the electron transport and increases ROS production to amplify mitochondrial dysfunction61 and peroxynitrite formation59

Such findings reinforce our hypothesis that mitochondrial transplantation contributes to bioenergetic improvement in P301L cells through both increased mitochondrial mass and enhanced efficiency of the mitochondrial network