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Low GI diets have been shown to control blood glucose control better, increase insulin sensitivity, reduce serum cholesterol, reducing risk of developing type 2 diabetes, decrease risk of cardiovascular disease and improve weight control [41,42,43,44,45,46,47]

64 In chronic obstructive pulmonary disease, GSTM1/GSTT1 variants are associated with an elevated risk, particularly in cases of emphysema

Conversely, exosomes may also confer resistance to ferroptosis in tumor cells (123)

Competing interest The authors declare that they have no competing interests

In IDD, there is increased expression of matrix-degrading proteins such as matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTs) resulting in deregulation of the normal homeostatic mechanism (Le Maitre et al., 2007)