melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight ⬆️ in single basal melanocytes; NO nests. More info like this in Labial melanotic macule

An additional contraindication to PDE-5 inhibitor use is prior diagnosis of nonarteritic ischemic optic neuropathy (NAION), a rare ophthalmologic disorder

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Relationships between MC4R levels and metabolic outcomes were explored through multivariate and regression analyses

UV-induced pigmentation is primarily a tyrosinase upregulation response tyrosinase inhibitors are the most direct intervention

This condition is characterized by a persistent lack of sexual desire and is considered one of the most common forms of sexual dysfunction