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Secondly, there are multiple issues in the development of LAM vaccines, including the lack of reliable preclinical evaluation indicators, suitable animal models for vaccine assessment, methods for simulating exposure, unified clinical trial endpoint standards, consistent evaluation environments, and complex immune populations (200)

Stroke 2007;38:18559

These molecular alterations are indicative of a negative prognosis for patients (Table I) (32,33,34)

Cathelicidin LL-37 induces the generation of reactive oxygen species and release of human -defensins from neutrophils