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The extraction solvents consisted of acetonitrile/water (1:1, v/v) containing either 5% (v/v) MPA, 5% (v/v) SSA, or 5% (v/v) TFA

TOP THE GUIDELINES AND PROTOCOLS ADVISORY COMMITTEE The principles of the Guidelines and Protocols Advisory Committee are to: encourage appropriate responses to common medical situations recommend actions that are sufficient and efficient, neither excessive nor deficient permit exceptions when justified by clinical circumstances Contact Information: Guidelines and Protocols Advisory Committee PO Box 9642 STN PROV GOVT Victoria BC V8W 9P1 Email: [email protected] Website: www.BCGuidelines.ca Disclaimer The Clinical Practice Guidelines (the Guidelines) have been developed by the Guidelines and Protocols Advisory Committee on behalf of the Medical Services Commission

No evidence of hormonal, hepatic, or systemic adverse effects has been observed in available data