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Description

Metalloreductase six-transmembrane epithelial antigen of prostate 3 (STEAP3) possesses ferrireductase activity, reducing Fe to Fe 2 , which is then released into the cytoplasm via DMT1, contributing to an unstable iron pool (Pantopoulos, 2004

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Emerging evidence also implicates Exos in modulating the tumor microenvironment to reduce ferroptosis resistance in cancer [17]

Moreover, GSTs are involved in multidrug resistance in various cancers by facilitating the detoxification of anti-cancer drugs and interacting with efflux pumps, such as multidrug resistance protein 1 (MRP1) and P-glycoprotein, which can decrease drug efficacy