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264 Therapeutic targeting of the UPR and ERAD in cancer IRE1 inhibitors UPR signaling and ERAD are critical adaptive pathways that allow cancer cells to survive chronic ER stress

10.1016/j.pnpbp.2019.109812 Prog

MeHgs effects on GSH homeostasis are depicted in Figure 2

The objective of this work was to bring together all scientific and patient-related data regarding oral absorption, dosage, and clinical effects in a fusion which has clinical relevance to serve as guidance for the clinician before more robust and well-designed trials can be conducted to provide the many answers which still elude us about this very promising treatment

Shih, A