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216-218 The mechanisms underlying synergy between checkpoint inhibitors and blockade of TGF- signaling or activation are the focus of current investigation, and these pre-clinical results have led to active clinical trials evaluating TGF- or v8 integrin inhibitors in patients with cancer

Pre-weaning manganese exposure causes hyperactivity, disinhibition, and spatial learning and memory deficits associated with altered dopamine receptor and transporter levels

21 Previous studies have shown that Src kinases, such as Lyn and Hck, play pivotal roles in integrin-mediated neutrophil activation, 367,368,369 with combined deletion severely impairing neutrophil phagocytosis 370 and abrogating their pro-inflammatory responses in autoimmune disorders

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