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Similar content being viewed by others Background Consistent data from multiple studies (in vitro and in vivo) demonstrate the association between IGF-1 deficit and deregulated lipid metabolism, cardiovascular disease (CVD), diabetes, and altered metabolic profile of diabetic patients

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Biochemistry 37 , 1323913249 (1998)

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Inadequate use of vitamin B 12 , which may occur if antimetabolites for the vitamin are employed in the treatment of neoplasia Pernicious anemia is the most common cause of vitamin B 12 deficiency