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In the formation of TLS, because an enormous number of immune cells are ectopically recruited to nonlymphoid organs, it is speculated that dramatic metabolic remodeling occurs in immune cells in the organ

Cheng SB, Lu GQ

Escalation Therapy: Higher-intensity interventions reserved for refractory or severe symptom flares and used under close clinical supervision

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Further studies are needed to determine if regulated expression of p21, CASP-2, CASP-9, SOD-1 and HO-1, components of the anti-oxidant glutathione metabolic pathway GP-1 and GR-1, and the DNA damage marker GADD45 are necessary to complete differentiation in specialised keratinocyte layers