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Advances in genomics, proteomics and metabolomics will help us to further understandthe causes of type 1 and type 2 diabetes and could eventually lead to novel therapeutic approaches.
Other clinically effective interventions include the normalization of epidermal homeostasis and the active restoration of the dermal fibroblastic microenvironment, together with anti-inflammatory agents and those aimed at reducing vascularization impact
Clinical data are summarised in Supplementary Table a
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