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Evidence type: Human RCT | Observational | Animal | In vitro | Regulatory Mechanism of Action 5-Amino-1MQ works by blocking the NNMT enzyme , which is responsible for consuming nicotinamide and depleting NAD+ stores

David Sinclair, a leading voice in longevity research, has stated: NAD+ is the closest we've gotten to a fountain of youth.[2] His research highlights how NAD+ activates pathways that mimic caloric restriction, a known extender of lifespan in models

[DOI] [PMC free article] [PubMed] [Google Scholar] 264.Tsai, S.-Y

Reported symptoms include headache, nausea, diarrhea, facial flushing, and in rare cases, skin rash or tingling