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Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, certain endocrine disorders, iron deficiency, and subtotal gastrectomy)

B12 injections are ideal for those who: Have a diagnosed B12 deficiency Dont absorb B12 well from food or supplements Need fast symptom relief If you are following a vegan or vegetarian diet (since B12 is found mostly in animal products) Your provider may recommend blood testing to confirm a deficiency and tailor a dosing schedule that fits your goals

[Pernicious anemia: masking of B12 vitamin deficiency by folic acid]

BMJ 2003;327:55760