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In the absence of AChE, sustained ACh stimulation induces a prolonged Ca ++ influx which activates calpain, a protease constitutively inhibited by rapsyn, triggering AChR cluster dispersal mediated by Cdk5 (Lin et al., Another negative regulator of the clustering pathway is the SRC homology two domain-containing phosphotyrosine phosphatase 2 (SHP2)

GS hematin stability in the presence of hydrogen peroxide The degradation of hematin in the presence and absence of GSH (2 mM) induced by H 2 O 2 was monitored by the change of absorption at 618 nm

The principal reactions and proteins responsible for reducing GSSG to GSH in plants are relatively well characterized

doi: 10.1016/j.cell.2006.02.049 24 BartschererKPelteNIngelfingerDBoutrosM

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