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This metabolic imbalance contributes to increased lipid peroxidation, as indicated by high malondialdehyde (MDA) levels ( These mitochondrial impairments not only compromise energy production but also act as pro-inflammatory stimuli, promoting chronic neuroinflammation through dysregulated mitochondrial signaling and innate immune response

Therefore, rigorous safety evaluations are essential to address the potential adverse effects and toxicity of plant products, which is crucial for patient safety

Quercetin is obtained from Capers (the fruits of the caper bush called Caperberries)

How the four axes of cellular iron regulation described (IRE-IRP, PHD-HIF, KDM3B-mTOR-TTP, and haem-HRI) act in concert, and in different cell types across different anatomical sites and tissues where local concentrations of iron may fluctuate substantially, is unknown

Funding This study was funded by the Natural Science Foundation of Heilongjiang Province (LH 2022H109)