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The development of DFU begins with a mechanical injury or pressure on the foot, often due to neuropathy, which impairs the ability to sense pain and prevent tissue damage

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This review highlights how antimicrobial peptides, angiogenic peptides, cell-penetrating peptides, and ECM-mimetic peptides (ECM = extracellular matric) are being engineered into hydrogels, nanofibers, and smart dressings to overcome limitations of traditional wound therapies