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Primary biliary cholangitis classically presents with severe fatigue, pruritus, hepatomegaly, and elevated alkaline phosphatase due to progressive destruction of intrahepatic bile ducts

VNN1, a potential biomarker for pancreatic cancer-associated new-onset diabetes, aggravates paraneoplastic islet dysfunction by increasing oxidative stress

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Moreover, increased IGFBP-3 protease activity in these tumors facilitates the formation of binary complexes as well [8,15,16]