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A series of selective inhibitors of iNOS have been developed and in a study, one of these, the pro-drug of L-N6-(1-imminoethyl)lysine gave a lasting reduction in NO concentrations in exhaled breath [126], suggesting that the inhibition of peroxynitrite generation by antioxidants or iNOS inhibitors offers a therapeutic approach in emphysema and may restore corticosteroid responsiveness

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But it can be a contributing factor that amplifies everything else and unlike many of those other variables, it's straightforward to identify and correct

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