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A study investigated the possible pathway by which H 2 O 2 induced apoptosis in glioma cells and concluded that oxidative stress inhibited glioma cell growth and induced apoptosis via a caspase-3-dependent pathway (Liu et al., 2015)
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Interestingly, decaffeinated coffee and nicotine-free tobacco were neuroprotective in a Drosophila model of PD, but, the neuroprotection depended on the cytoprotective transcription factor nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) and cafestol (an activator) (Trinh et al., 2010)
It binds to its receptors on Leydig cells, triggering a cascade of intracellular signaling events [30]
